It can be done but it seems some people have had much better luck than others with the same setups. Below is what I have found over the years. Unfortuately I did not run these at the track so I dont have slips with exact numbers. Im comparing them to other vehicles I have owned, tuned / driven that have been run at the track. One thing to remember is a stripped down van is not that much heavier than the FWD cars.
I have both auto and stick turbo vans the 84 is a 5-spd (A520) 2.5, probe intercooler with a garrett, backcut valves, no balance shafts, 244 pump, 20+ injectors, AFPR and 16 psi. The van is tons of fun around town. Comparing it to other vehicles and what times they ran I would say 15 flat. The problem I found is with the garrett it spools up fast but it makes the van feel like it runs out of breath very fast. It is still a much better turbo than the small mitsu.
My 89 had a 2.5 with a 46 trim, G-Head TU header, no balance shafts, wiseco's, Custom tune 18 PSI. Volvo cooler, 255 pump Auto ( with wrong converter -- not a high enough stall). This just plain sucks..... "NO G-Head "
Same van with mild ported swirl, 340 pump, and wrong converter. It definately more power than the 84. I know for sure it was quicker than my Pontiac GTP which stock runs 15 flat so im guessing mid 14's. But Paul smith ran a 12.65 on the same basic setup...
Same van above with a 2.4 DOHC, 46 trim, 1mm os valves, eagel rods, CP dished pistons, all balanced, 40+ injectors, 1st gen DOHC neon intake, NPR intercooler, Very conservative timing, 31th trans with high stall converter, @10 psi it runs better than all of the above. This is the first combo I actuially have a feeling has the potential of mid 12's. It is also the most responsive outsde of boost as well.
If your looking for a van at the strip I would say auto would be best but there is nothign wrong with a stick at the track. Just make sure cables are good and or go with heim joint cables. To me the shifters in the vans seem sloppy..